Oral or transdermal hormones cause roller coaster hormone levels, resulting in drastic fluctuations in energy and mood. BioTE pellet therapy is different due to its delivery method. Estrogen and testosterone are shaped into small pellets about the size of a grain of rice by a compounding pharmacist. These pellets are then placed in the fat just beneath the skin in a painless, in-office procedure. The pellet releases hormones via cardiac output as needed, resulting in a consistent release of estrogen and testosterone.